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            目錄肽產(chǎn)品
            OREX-001B
            Orexin A, human
            Glp-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2(Cys6&Cys12 bridge , Cys7&Cys14 bridge)
            Size:1.0
            P1(RMB):2758
            MW:3561.2
            One letter sequence:Glp-PLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2(C6&C12 bridge , C7&C14 bridge)
            Molecular Formula:C152H243N47044S4
            Description:Hypothalamic neuropeptide that regulates feeding behavior and significantly augments food intake in a dose-dependent manner when a bolus is administered intracerebroventricularly. After a 48-hour fast, hypothalamic prpro-orexin mRNA level is up-regulated 2.4. The discovery of orexins and their receptors may provide a novel molecular basis for understanding the role of the lateral hypothalamic areas in the regulation of energy homeostasis.
            Literature Reference:M.W. Schwartz, Nature Med., 4, 385 (1998); T. Sakurai et al., Cell, 92, 573 (1998)
            Cas:
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