Size：0.25
P1(RMB)：529
MW：3610.2
One letter sequence：Biotin-KGWHLKSK-K(Ac)-GQSTSRHKKLMFKTEGPDSD-NH2
Molecular Formula：
Description：This is a biotin-labeled and amidated peptide derived from residues 368-393 of human p53 tumor suppressor protein with acetylation at Lys373 and additional KGW residues on its N-terminus. Activated p53 functions to induce cell cycle arrest and apoptosis in response to signals such as DNA damage. Acetylation of p53 reduces ubiquitination by MDM2 and increases p53 half-life in vivo.
Literature Reference：Kubbutat, M. et al. Lett Nature 387, 299 (1997)\nLi, M. et al. J Biol Chem 277, 50607 (2002).
Cas：