Size：1
P1(RMB)：340
MW：1645.9
One letter sequence：SHLVEALYLVCGERG
Molecular Formula：C72H116N20O22S
Description： This insulin B-chain peptide binds to a MHC-II allele called I-Ag7. A number of autoimmune diseases has been linked to class II proteins encoded by the MHC. Type 1 diabetes, or insulin-dependent diabetes mellitus, is a T cell-mediated disease that results in autoimmune destruction of pancreatic ? cells leading to hyperglycemia. This insulin B peptide may be a self-antigen candidate that could initiate the disease. Immunization with this peptide in mice led to autoantibodies and insulitis.
Literature Reference：Devendra, D. et al. Diabetes 54, 2549 (2005). \nStarwalt, S. et al. Protein Eng. 16, 147 (2003); \nLee, L. et al. PNAS 102, 15995 (2005).
Cas：