Size：1.0
P1(RMB)：828
MW：1573.8
One letter sequence：Dabcyl-LAQAVRSSSR-Edans
Molecular Formula： C70H104N22O18S1
Description：TACE FRET substrate I that is derived from the cleavage sequence of pro-TNFa recognized by the TNFa-cleaving enzyme (TACE). TNFa is presumably shed from cell membranes by TNFa-cleaving enzyme (TACE). Incubation of the TACE substrate with recombinant human TACE gives a specific cleavage to restore the quenched fluorescence. The substrate is widely used to screen inhibitors of TNF-convertase.
Literature Reference：A.J. H.Gearing et al., Nature , 370, 555 (1994)\nK.M. Mohler et al., Nature , 370, 218 (1994)\nBecker BF, et al. (2002).Biol Chem 383, 1821-6, \nMohler KM, et al. (1994). Nature 370, 218-20\n
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